-
37浏览
-
0点赞
-
0收藏
-
0分享
-
33下载
-
0评论
-
引用
期刊论文
Different synaptic mechanisms of long-term potentiation induced by nicotine and tetanic stimulation in hippocampal CA1 region of rats
Acta Pharmacol Sin 2003 May; 24 (25): 398-402,-0001,():
AIM: To investigate whether long-term potentiation (LTP) induced by nicotine and tetanic stimulation in the hippocampal CA1 region shares differentmechanisms. METHODS: Extracellular population spikes of the pyramidal cell layer in the hippocampal CA1 region were recorded in vitro. RESULTS: LTP induced by the tetanic stimulation could be facilitated by nicotine 10μmol/L, meanwhile, the tetanic stimulation did the same effect on LTP induced by nicotine 10μmol/L. MK-801 10μmol/L or NG-nitro-L-arginine methyl ester (L-NAME) 20 μmol/L blocked LTP induced by tetanic stimulation, but did not inhibit LTP induced by nicotine. CONCLUSION: LTP induced by nicotine shares different synaptic mechanisms with LTP induced by tetanic stimulation.
【免责声明】以下全部内容由[陈汝筑]上传于[2009年05月08日 16时59分41秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。
本学者其他成果
同领域成果