-
64浏览
-
0点赞
-
0收藏
-
0分享
-
327下载
-
0评论
-
引用
期刊论文
The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts
X. -G. Chen et al. Biomaterials 23 (2002) 4609-4614,-0001,():
In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast. r 2002 Elsevier Science Ltd. All rights reserved.
【免责声明】以下全部内容由[陈西广]上传于[2007年03月27日 13时41分39秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。
本学者其他成果
同领域成果