This paper presents a systematic methodology for modeling and analysis of manufacturing supply chain business processes. The proposed approach "rst employs Computer Integrated Manufacturing Open System Architecture (CIMOSA) behavior rules to model the business process routing structures of manufacturing supply chain networks. Object-oriented predicate/transition nets (OPTNs) are then developed for the modular modeling and analysis of process models. Based on the structure of OPTNs, a procedure to obtain the system's P-invariants through objects' P-invariants is suggested. From the P-invariants obtained, system structural properties such as deadlock and over#ow can be analyzed. By using Petri net unfolding techniques and by extracting the process model of each object from the entire process model, the sequencing analysis for operations in supply chain processes becomes possible. Several manufacturing supply chain examples are used to illustrate the e!ectiveness of the proposed method.