The purpose of these experiments is to study the effects of Chinese herbal medicinal ingredients (CHMIs) on peripherallymphocyte proliferation and serum antibody titer in chicken vaccinated with Newcastle disease (ND) vaccine. Nine CHMIswere chosen for the experiments. Astragalus polysaccharide (APS), Isatis root polysaccharide (IRPS), Epimedium flavone(EF), Propolis flavone (PF), Astragalosides (AS) and Ginsenosides (GS) could promote lymphocyte proliferation andantibody titer, while Epimedium polysaccharide (EPS) mainly stimulated cellular immune responses. Chinese angelicapolysaccharide (CAPS) and Propolis polysaccharide (PPS) exerted weaker effects on promoting immune responses. APS,IRPS, PPS and PF in promoting lymphocyte proliferation, and IRPS, PPS, EF and PF in promoting humoral immunity inhigher dose were significantly stronger than in lower dose. Our results indicated that almost all of the nine CHMIs couldpromote both humoral and cellular immune responses and would be expected as the component drug of a new-typeimmunopotentiator.