提示
刘杰
-
43浏览
-
0点赞
-
0收藏
-
0分享
-
143下载
-
0评论
-
引用
期刊论文
Human S15a Expression Is Upregulated by Hepatitis B Virus X Protein
MOLECULAR CARCINOGENESIS 40: 34-46 (2004)，-0001，（）：
The hepatitis B virus (HBV)-encoded X antigen (HBxAg) may contribute to the development of epatocellular carcinoma (HCC) through the upregulated expression of selected cellular genes. To identify these genes, RNAs isolated from HBxAg-positive and -negative HepG2 cells were compared by PCR select cDNA subtraction. One gene overexpressed in HBxAg-positive cells by Northern and Western blotting is the ribosomal protein S15a. The S15a mRNA is 535 base pairs, encoding a protein 130 amino acids long with a molecular weight of 14.3kDa. S15a expression was upregulated in HBV-infected livers, where it costained with HBxAg. Overexpression of S15a stimulated cell growth, colony formation in soft agar, and tumor formation in SCID mice. Hence, HBxAg upregulated the expression of S15a, the latter of which participates in the development of HCC, perhaps by altering the integrity of translation.
【免责声明】以下全部内容由[刘杰]上传于[2005年05月16日 22时45分49秒]，版权归原创者所有。本文仅代表作者本人观点，与本网站无关。本网站对文中陈述、观点判断保持中立，不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担全部责任。
本学者其他成果
同领域成果
