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李元建

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期刊论文

Reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril: a role of calcitonin gene-related peptide

李元建Zhi-Hong Zhou Jun-lin Jiang Jun Peng Han-Wu Deng Yuan-Jian Li*

European Journal of Pharmacology 439(2002)129-134,-0001,():

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摘要/描述

Previous studies have shown that the development of tolerance to nitroglycerin is related to a decrease in the release of endogenous calcitonin gene-related peptide (CGRP). In the present study, we explored whether endogenous CGRP is involved in reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril in rats in vivo and vitro. Tolerance was induced by exposure to nitroglycerin (4.4

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