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期刊论文
创面难愈机制研究——糖尿病皮肤的“微环境污染”
中华烧伤杂志,2008,24(1):3~5,-0001,():
Impaired wound healing in diabetes is a significant clinical problem which is thought to be associated with neuropathy and angiopathy previously. The present study indicates that accumulation of glucose and g]ycometabolic products in skin tissue, as the result of glyeometabolic disorders, which contributes to cutaneous environmental alterations in diabetes mellitus, and subsequently induces the abnormal cell behaviors, cytokine alteration and matrix modification. Thus, diabetic neuropathy and angiopathy might be regarded as the pathological outcome of cutaneous environmental alterations. In conclusion, glycometabolism disorders could be described as one of the initial events for the alteration involving in the underlying cutaneous disorder which impair healing process. The related research focuses on the initial event of controlling disorders in wound healing and therefore contribute to providing the strategy of treatment as based on these approaches.
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