Essential Hypertension (EH) is correlated with a metabolic disturbance characterized by insulin resistance (IR). In this study, there were observed in 47 subjects with EH and 30 subjects with normal blood pres-sure. Serum levels of Insulin-like growth factor-1 (IGF-1), serum levels of growth hormone (GH), the act v-ity of erythrocyte Insulin receptors (EIR), and ATP levels In erythrocytes, the insulin sensitivity index (ISI) was used to study the correlative factors of essential hypertension. 1. Among patients with EH, [SI. GH, and low-affinity Insulin binding sites of EIRs (RT2) were found to be in significantly lower amounts, IGF-1 levels and the KD2 of the erythrocyte insulin receptors were noted to be significantly h]gher. Compared with the control group, there was a mart ed digerenca between EH group and the control group. However, no statisgcal difference was observed between the hypertensive group and the group with normal blood pressure as regards erythrocyte ATP levels, high-affinity fnsulin binding sites of EIRs (RT1). and the KD of EIRs. 2. In the hypertensive group, the ISI was negatively correlated with mean arterial blood pressure (MBP), a family history of hypertension. the body mass index (BMI), the waist-hip ratio (WHR) and IGF-1 levels (r=-0.614△, -0.354**, -0.386**, -0.472**, -0.298*, △ρ<0.001, **ρ<0.01, *ρ<0.05), were positively correlated with RT2 and GH levels (r=0.301**, 0.275*, **p<0.01, *p<O.05), There were no statistically significant differences betwe ISI and age, sex, smoking history, drinking, RT1, KD1, and ATP levels In erythrocytes. 3, The ISI was user as the dependent variable in multiple linear stepwise regression analysis. MBP (X1), a famity history of ER (X2), WHR (X2), GH (X4), IGF-1 (X5), RT2 (X6), and the body mass index (X7) was used as independent variables. X1, X2, X3, X5, X6, and X7 were used in the eclualions, The results indicate that petients with EH also tend to have IR. We suggest that MBP, a family history of ypertension. BMh WHR, IGF-1, and RT2 might be independent factors affecting IR in cases of essantial hypertension.