Susceptibility to motion sickness (MS) is known to beaffected by gender and ethnic origin, but whether gender and ethnicityare interacting is unknown. Methods: We investigated MS developmentin healthy Caucasian subjects (n±227), and in subjects of Chineseorigin (n±82). All subjects were exposed to nausea-inducing bodyrotations in a rotation chair, and rotated around the yaw axis for 5±1min, while they were instructed to move their heads. Prior to rotation,subjects had to fill out a motion-sickness susceptibility questionnaire(MSSQ). Total rotation tolerance time (RT) was noted. Symptom ratings(SR) were performed at the beginning, and immediately after the end ofeach rotation, and 15 and 30 min later. Results: The average RT wassignificantly higher in Caucasian (163±6s) than in Chinese subjects(111±7 s) (F±24.84, p±0.0001). The adult MSSQ score wassignificantly lower in Caucasians (17.8±1.1) than in Chinese volunteers(24.2±2.1) (F±6.05, p ±0.014). Maximal SR post rotation wassimilar in Chinese and Caucasian subjects. RT was highly predictablefrom the MSSQ scores, but separate for both genders. Conclusion:Susceptibility to MS is affected by both ethnic origin and by gender in arather complex fashion. The most reliable prediction of RT can be basedon the individual’s history as assessed by the MSSQ.