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The protective effects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats

沈玉先Y. X. Shen S. Y. Xu W. Wei X. X. Sun L. H. Liu J. Yang and C. Dong

J. Pineal Res. 2002; 32: 85-89,-0001,():

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摘要/描述

This work investigated the ability of melatonin to prevent oxidative damage in brain tissue induced by injection of beta-amyloid peptide 25-35 (Ab25-35) in middle-aged rats. The Morris water maze was used to evaluate the cognitive function of the rats. Thiobarbituric acid-reactive substances and antioxidative enzymes (superoxide dismutase and glutathione peroxidase) activities were measured. It was found that injection of (Ab25-35) (20

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