-
24浏览
-
0点赞
-
0收藏
-
0分享
-
75下载
-
0评论
-
引用
期刊论文
Dinuclear macrocyclic polyamine zinc (Ⅱ) complexes: Syntheses, characterization and their interaction with plasmid DNA
Journal of Inorganic Biochemistry 99(2005)1661-1669,-0001,():
The syntheses, characteristics of dinuclear macrocyclic polyamine zinc complexes and their interaction with plasmid DNA are reported. The two cyclen (1,4,7,10-tetraazacyclododecane) moieties are bridged by rigid and flexible linkages. The crystal structures of Zn2C27H43N8O15Cl4 [5c•(ClO4)3•2H2O] and Zn2C30H43N10O13Cl3 [5e•(ClO4)3•H2O] have been determined. The complexes crystallize in the monoclinic space group C2/c and P2(1)/c with the following unit cell parameters: 5c• (ClO4)3 •2H2O: a=32.568(4) Å, b=14.8593(17) Å, c=19.443(2) Å, a=90.00º, b=119.435(4)º, c=90.00º, Dc=1.551 mg/m3, FW=956.71, F(000)=3932; 5e•(ClO4)3 Æ H2O: a=15.807(2) Å, b=16.756(2)Å, c=16.161(2) Å, a=90.00º, b=97.062(4)º, c=90.00º, Dc=1.546 mg/m3, FW=988.83, F(000)=2032. The distance between the two Zn(II) ions is about 4.0 Å. The structures show that two zinc ions can synergistically interact with the substrate DNA. With this novel structural characteristics, the dinuclear macrocyclic polyamine Zn(II) complexes via the synergetic effect between the two zinc ions can catalyze the cleavage of plasmid DNA (pUC18) with unprecedented speed at physiological conditions.
【免责声明】以下全部内容由[余孝其]上传于[2009年04月28日 09时28分08秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。
本学者其他成果
同领域成果