BACKGRoUND&oBJECTlVE: Vascular endothelial growth factor (VEGF) famify is related to angiogenesis． VEGF-A and VEGF-C are closely related to tumorigenesis and lymphatic metastasis． This study was to detect the expression of VEGF-A and VEGF-C in breast cancer． and explore their correlation to celI proliferation, microvessel density (MVD), and lymphatic metastasis of breast cancer．METHODS：The expression of VEGF-A, VEGF-C, proliferating cell nuclear antigen (PCNA), and CD34 in 98 samples of breast cancer were detected by SP immunohistochemistry． RESULTS: The positive rate of VEGF-A was 85.7%: that of VEGF．C was 90．8% The positive rates of VEGF-A and VEGF-C were significantly higher in cancers with lymph node metastasis than in cancers without lymph node metastasis (P<0.05) The positive rate of PCNA was 98．O%: its expression level was increased with the expression levels of VEGF．A and VEGF-C f r=0.432, P=0.000; r=O．294, P=0．001) MVD was significantly higher in cancers with lymph node metastasis than in cancers without lymph node metastasis (64 26.26．40vs． 5O．29.29．35, P<0.05)．MVD was positively correlated to the expression of VEGF-A (r=0．327． P<O O01), but had no correlation to VEGF-C (r=0.123，P>O．O5)．C0NCLUSIONS：VEGF-A mainly mediates angiogenesis, cell proliferation, and metastasis of human breast cancer． VEGF-C promotes celI proliferation of human breast cancer: it is correlated to lymph node metastasis，but has no correlation to MVD．