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期刊论文
Fluorescence enhancing by alkaline degradation of tetracycline antibiotics and its application
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Tetracyclinea ntibiotics could be degraded after being heated in boiling-water bath in alkaline solution (in KOH medium). The fluorescence excitation and emission wavelengths of the degradation products changed and the fluorescence intensity increased by 5-190 folds as compared with that of antibiotics themselves. It was considered that there occurred a nucleophilic ring rupture reaction to form the degradation products with lactonic structure. The interaction of the lone pair electrons of oxygen on the degradation products with the conjugated n electrons induced the increase of the delocalization for the conjugated electron system in the molecule and thus enhanced the fluorescence intensity.
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