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期刊论文
Association of(S)- Isoserine Derivatives and 2, 2, 4- Trimethyl- 3- hydroxy- 4- cyclohexenecarboxylate
CHEM. RES. CHINESE U. 2007, 23(1), 18- 21,-0001,():
Two novel compounds(4a and 4b) were obtained by the association of 2, 2, 4- trimethyl- 3- hydroxy- 5- cyclohexene- carboxylate with(S)- isoserine derivatives. The space location of the hydroxyl group of compound 1 was identified via the formation of lactone 6. Fe2(SO4)3·H2O was used as the catalyst for the synthesis of lactone 6. The carboxyl group was selectively protected with diazomethane. All the products were characterized via 1H NMR and mass spectra. The Docking study showed that the associations have the potential therapeutic use of DPP- Ⅳ inhibitor.
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