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Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes
ZENG Jun 1,WANG Gefei 2,LI Weizhong 2,CHEN Xiaoxuan 2,XIN Gang 2,ZHANG Dangui 2,JIANG Zhiwu 2,LI Kangsheng 2 * #
1.Department of Immunology and Microbiology, Shantou University Medical College, GuangDong ShanTou 515041
2.Department of Immunology and Microbiology, Shantou University Medical College, Shantou 515041
*Correspondence author
#Submitted by
Subject: Human Immunology
Funding: Specialized Research Fund for the Doctoral Program of Higher Education (No.20094402110004), The study was supported by grants National Natural Science Foundation of China (No.30972766, 31170852, 81001322, 8117279)
Opened online:16 January 2013
Accepted by: none
Citation: ZENG Jun,WANG Gefei,LI Weizhong.Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes[OL]. [16 January 2013] http://www.paper.edu.cn/en_releasepaper/content/4513097
 
 
Coxsackievirus commonly infects children and occasionally causes severe meningitis and/or encephalitis in the newborn. The underlying mechanism(s) behind the central nervous system pathology is poorly defined. It is hypothesized that astrocytes may be involved in inflammatory response induced by CVB3 infection. Here we discuss this hypothesis in the context of CVB3 infection and associated inflammatory response in primary mouse astrocytes. CVB3 infected and replicated in astrocytes, with release of infectious virus particles. CVB3 induced cytopathic effect (CPE) and production of proinflammatory cytokines IL-1β, TNF-α, IL-6, and chemokine CXCL10 from astrocytes. These data suggest that direct astrocyte damage and cytokines induction could be a mechanism of virus-induced neuropathology.
Keywords:viral infection; coxsackievirus; astrocyte; cell death; cytokine; neuroinflammation
 
 
 

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