生物降解材料乳酸-乙醇酸共聚物在药物传输中的应用
首发时间:2003-10-26
摘要:乳酸/乙醇酸共聚物(PLGA)在药物控释领域具有广泛应用。其中,载药微球是PLGA药物控释系统中最常用的剂型。本研究中,作者选用孕酮为模型药物,以自己实验室合成的系列PLGA制备载药微球,微球制备中采用了不同共聚物组成和不同分子量的PLGA。显微镜观察表明获得的微球为非粘连的球形颗粒,载有孕酮的PLGA微球的粒径分布呈高斯分布,平均粒径为70至134微米。本研究采用溶剂提取法制备载药微球,此药物包封方法获得的微球药物包封率高。我们进一步研究了载有孕酮的PLGA微球的药物释放性能及影响因素,结果表明,微球的释放性能受聚合物性能的影响,采用乙醇酸链段含量较高的PLGA制备的载药微球药物释放速率较快;同样,微球中的药物含量也对其药物释放有影响,孕酮含量较高的微球的药物突释效应较为显著。
关键词: 乳酸-乙醇酸共聚物, 微球 孕酮 控制释放 药物传输
For information in English, please click here
Drug delivery application of biodegradable lactic/glycolic acid polymers
Abstract:Lactic/glycolic acid polymers (PLGA) are widely used for drug delivery systems. The microsphere formulation is the most interested dosage form of the PLGA-based controlled release devices. In this study, the previously reported PLGA were used to prepare drug-containing microspheres. Progesterone was used as a model drug. The progesterone microspheres were prepared from PLGA having varied compositions and varied molecular weight. The microscopic characterization shows that the microspheres are spherical, non-aggregated particles. The progesterone-containing PLGA microspheres possess a Gaussian size distribution, having average size from 70 to 134 m. A solvent extraction method was employed to prepare the microspheres. The microencapsulation method used in this study has high drug encapsulation efficiency. The progesterone release from the PLGA microspheres and the factors affecting the drug release were studied. The release of progesterone from the PLGA microspheres is affected by the properties of the polymer used. The drug release is more rapid from the microspheres prepared using the PLGA having higher fraction of glycolic acid moiety. The drug release from the microspheres composed of higher molecular weight PLGA is faster. The drug content in microspheres also has an effect on the drug release. Higher progesterone content in microspheres yields a quicker initial burst release of the drug.
Keywords: poly(lactic-co-glycolic acid), microspheres, progesterone,
基金:
论文图表:
引用
No.31661067178870****
同行评议
共计0人参与
勘误表
生物降解材料乳酸-乙醇酸共聚物在药物传输中的应用
评论
全部评论0/1000