抑制素α亚基在大鼠下丘脑与垂体的免疫组化定位
首发时间:2004-02-23
摘要:为研究抑制素通过血脑屏障的转运机理,给性成熟去卵巢大鼠颈静脉注射不同剂量的抑制素α片段和含抑制素α亚基的猪卵泡液抑制素粗提物,分别在注射后不同时间用抑制素α亚基单克隆抗体检测下丘脑、垂体的免疫反应。结果表明,在下丘脑与垂体存在抑制素α亚基单克隆抗体的特异性阳性反应位点,并存在剂量与时间上的依赖关系,说明抑制素α亚基可以通过血脑屏障到达神经中枢,可能存在抑制素α亚基在血脑屏障的转运机制。
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Immunohistochemical localization of inhibin α subunit in hypothalamus and pituitary of the rat
Abstract: In order to study the mechanism of inhibin transport through the blood-brain barrier,sexually matured ovari-ectomized rats were injected with inhibin α subunit crude abstracts and different levels of inhibin α subunit fragments. Immunohistochemical localization of inhibin α subunit with inhibin α subunit mono-cloning antibody was performed at different times post the injection. The results showed that positive reaction sites in dose and time dependant ways were detected in the hypothalamus and pituitary, suggesting that inhibin α subunit could pass through the blood-brain barrier arriving at hypothalamus and pituitary, and a passage mechanism of the subunit through the barrier might exist.
Keywords: inhibin blood-brain barrier transport mechanism
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No.3062904107750776****
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