CD44v6在口腔鳞癌中的表达
首发时间:2004-02-16
摘要: 目的 观察细胞黏附分子CD44v6在口腔鳞癌中的表达,了解其与口腔鳞癌组织学分级,肿瘤浸润和转移的关系. 方法 运用免疫组织化学SP法测定30例口腔鳞癌和5例正常口腔粘膜组织中CD44v6的表达.结果 CD44v6在正常口腔黏膜组织呈强阳性表达,癌组织中CD44v6的表达明显弱于正常组织,在30例鳞状细胞癌的免疫组织化学染色中大部分鳞状细胞癌的癌细胞染色阳性. 但染色强度随肿瘤的分化程度不同而不同,分化高的癌巢上皮细胞膜染色均匀而浓重,分化差的癌巢上皮细胞膜染色弱而呈细线状. 转移灶内癌巢上皮CD44v6染色较弱. 结论 CD44V6的表达在判断癌的分化,浸润,转移中有重要意义
关键词: 口腔鳞状细胞癌;CD44v6 分化;黏附分子;免疫组织化学
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Expression of CD44v6 in Oral Squamous Cell Carcinomas
Abstract:BSTRACT:Objective To detect the expression of CD44v6 in oral squamous cell carcinoma (OSCC).The significance of CD44v6 in the differentiation, invasion and metastasis of OSCC was also evaluated. Methods Thirty samples of OSCC and five biopsies of normal oral mucosa were detected by immunohistochemical technique (SP method ) Results CD44v6 was strongly expressed in the nornal oral mucosa and adjacent non-cancerous tissue. Majority of 30 cases of squamous cell carcinoma were positive stained by immunohistochemical stain,but the stain degree was different relating to different differentiation degree of tumor. A heavy and even membrane stain was found in the high differential epithelial cell of carcinomas nest, and an uneven and thin linear stain pattern was present in the epithelia cell membrane of the low differentiated carcinoma nest, while the carcinoma epithelia in the metastatic nest was lightly stained with CD44v6. Conclusion The expression of CD44v6 is significant in carc
Keywords: oral squamous cell carcioma CD44v6 differential adhesion molecule immunohistochemistry
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