核因子кB在喉鳞癌组织及颈转移淋巴结组织中的表达
首发时间:2004-02-16
摘要:目的:探讨核因子кB(NF-кB)表达与喉癌生物学行为的关系.方法:应用免疫组织化学方法检测NF-кB p65在60例喉鳞癌组织,42例颈转移淋巴结组织及10例正常喉粘膜组织中的表达情况.结果:60例喉鳞癌组织中39例NF-кB p65阳性,阳性产物主要定位于肿瘤细胞胞浆.42例颈转移淋巴结组织中26例NF-кB p65阳性,10例正常喉粘膜组织中NF-кB p65无1例阳性表达.喉鳞癌组织与颈转移淋巴结组织间NF-кB p65的阳性表达率差异无显著意义. NF-кB p65的表达与患者的性别,年龄,喉癌组织学分型,T分期以及淋巴结转移无关. 结论: NF-кB p65是喉癌相关的一种癌蛋白; NF-кB p65蛋白表达可能是喉癌形成的一个早期事件,NF-кB p65蛋白可能为喉癌的一个新的肿瘤标志物.
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Expression of NF-кB in human laryngeal squamous cell carcinomas and cervical metastatic lymph node tissues
Abstract:bjective: To investigate the role and significance of NF-кB p65 protein in the occurrence and development of laryngeal squamous cell carcinomas. Methods: The expression of NF-кB p65 protein was studied immunohistochemically in 60 patients with laryngeal squamous cell carcinomas,42 patients with cervical metastatic lymph node tissues and 10 cases of normal laryngeal tissue. Results: Out of 60 cases of laryngeal squamous cell carcinomas,39 cases were found to have NF-кB p65 protein positive stain, 26 cases were found to have NF-кB p65 protein positive stain in 42 cases cervical metastatic lymph node tissues, while none of the 10 cases of normal tissue was found to have NF-кB p65 protein positive stain. The positive product was mainly localized in the cytoplasm of tumor cell. The expression rate of NF-кB p65 protein in laryngeal squamous cell carcinomas(65%)was significantly higher than that in normal tissue(0.0%) (P<0.01). The difference of NF-кB p65 protein expression between the laryn
Keywords: nuclear factor of kappaB(NF-кB) laryngeal neoplasms cervical metastatic lymph node immunohistochemistry
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No.2712591107689397****
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