VEGF-C和VEGFR-3在喉鳞癌及转移淋巴结组织中的表达
首发时间:2004-02-16
摘要:目的:探讨血管内皮生长因子C(VEGF-C)和血管内皮生长因子受体3(VEGFR-3)在喉鳞癌中的表达及其与喉癌生物学行为之间的关系.方法:采用逆转录聚合酶链式反应技术(RT-PCR),对30例正常喉黏膜组织、喉鳞癌组织及颈淋巴结组织中的VEGF-C、VEGFR-3基因表达进行检测. 结果:对同一患者, VEGF-C、VEGFR-3在喉鳞癌组织、颈淋巴结组织及正常喉黏膜组织中的表达有显著性意义(P<0.05),在喉鳞癌组织中,VEGF-C、VEGFR-3的表达与淋巴结转移以及病理分级有关,与患者年龄性别、病变部位、T分期无关. 结论:VEGF-C、VEGFR-3联合检测可望作为判断喉鳞癌患者预后的指标.
关键词: 血管内皮生长因子C;血管内皮生长因子受体3;喉鳞状细胞癌 淋巴转移
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Expression of VEGF-C and VEGFR-3 in human laryngeal squamous cell carcinomas and cervical metastatic lymph node tissues
Abstract:o study the gene expression of Vascular Endothelial Growth Factor C (VEGF-C) and Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) in laryngeal squamous carcinoma and their relation with clinic pathologic features. Method: VEGF-C and VEGFR-3 gene expression in 30 cases of normal laryngeal mucosa tissue(NLM), primary laryngeal carcinoma (PLC) and cervical lymph node (CLN) were examined by reverse transcription polymerase chain reaction (RT-PCR). Result: The gene expression of VEGF-C and VEGFR-3 is different among normal laryngeal mucosa tissue, primary laryngeal carcinoma and cervical lymph node in the same patient. In primary laryngeal carcinoma, Expression of VEGF-C, VEGFR-3 was significantly higher in lymph node positive group than in lymph node negative group and associated with histological grade of differentiation; The gene expression of VEGF-C, VEGFR-3 were not associated with age, sex, site, T stage. Conclusion: VEGF-C , VEGFR-3 have prognostic significance in laryngeal c
Keywords: Vascular endothelial growth factor C Vascular endothelial growth factor receptor 3 Laryngeal squamous carcinoma Lymphatic metastasis
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