液相色谱-串联质谱(LC/MS/MS)方法测定人血浆中佐米曲普坦的含量
首发时间:2004-11-24
摘要:本文建立了液相色谱-串联质谱(LC/MS/MS)方法测定人血浆中佐米曲普坦的含量。色谱柱:Zorbax Extend-C18柱,5 mm粒径,150×4.6 mm I.D.,美国Agilent公司;流动相:甲醇-水-甲酸(80:20:1,v/v/v);流速:0.8 mL/min。本方法具有良好的灵敏度、准确度、精确度以及专属性,完全适用于临床应用及药物代谢研究。
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Determination of Zolmitriptan in Human Plasma by Liquid Chromatographic Tandem Mass Spectromitry
Abstract:An analytical method based on liquid chromatography with tandem mass spectrometry detection was developed for the determination of zolmitriptan in human plasma. Column: Zorbax Extend-C18, 5 mm,150×4.6 mm I.D.,Agilent; mobile phase was methanol-water-formic acid (80:20:1,v/v/v) at a flow rate of 0.8 mL/min. This method is accurate, precise, sensitive and specific to be used in clinic applications and pharmacokinetics studies.
Keywords: zolmitriptan LC/MS/MS
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No.1284129121101260****
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液相色谱-串联质谱(LC/MS/MS)方法测定人血浆中佐米曲普坦的含量
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