含NURR1基因腺病毒对神经干细胞分化的影响
首发时间:2005-12-30
摘要: 目的 含NURR1 基因的重组腺病毒对神经干细胞分化的影响。方法 免疫组化观察转染腺病毒后C1712 神经干细胞后分化效率。结果 含NURR1 基因的重组腺病毒可使C1712 神经干细胞分化后近76 %细胞表现为神经元显型。结论 含NURR1 基因的腺病毒能明显的提高神经干细胞的分化效率。
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Adenovirus with NURR1 gene affecting on differentiation of neural stem cell
Abstract:Objective To observe the differentiation of neural stem cell infected by adenovirus with NURR1 gene (Ad - NURR1) . Methods To observe the differentiation of C1712 neural stem cell infected by Ad - NURR1 using an immunohistochemistry method1. Results Seventy -six percent cells showed phaenotype of neuron after C1712 neural stem cells infected by Ad - NURR1 differentiated1.Conclusion Ad - NURR1 could promote effective differentiation ratio of neural stem cells
Keywords: Parkinson disease Neural stem cell Adenovirus NURR1
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