丹参素的配位色谱分离研究
首发时间:2006-02-24
摘要:丹参素(Salvianic acid A)是一种水溶性酚酸类化合物,又名丹参酸甲, 其常用制剂主要用于治疗心脑血管疾病,为了最大限度的除去其他杂质成分的干扰,得到纯度更高的丹参素并且简化丹参素纯化的方法,往HPLC的流动相(甲醇:1%冰醋酸=15:85)中加入1mmol.l-1的硝酸银,在280nm处进行测定发现峰形良好。方法快速简便,专属性强,重现性好,可以作为丹参素分离制备检测的一种可靠方法。
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The study of Salvianic acid A’s Separation by Coordinate Chromatography
Abstract:Salvianic was a kind of water-soluble hydroxybenzene acid.It’s another name was Salvia miltiorrhiza Bge acid first.It’s preparation was always used to treat the disease of blood vessels of heart and cerebra.We added 1mmol/l silver nitrate into the mobile phase(methanol:1%acetic acid=15:85)for getting hold of more pure Salvianic acid A.We detected it at 281nm and found that the peak was good.The method was successfully applied to characterize,purify and determinate the Salvianic acid A.
Keywords: Salvianic acid A,HPLC,Silver nitrate
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