The Resistion toxicity of Assistant and Courier herbs in Long Dan Xie Gan Decoction containing Aristolochia Manshriensis Kom

• 1、Beijing University of Traditional Chinese Medicine

Abstract：Objective : To observe the renal function, histology in rats administered with Aristolochia Manshriensis Kom (AMK), Long Dan Xie Gan decoction(LDXGD) and Long Dan Xie Gan decoction removed Angelica sinensis,Rehmannia glutinosa Libosch and Glycyrrhizae uralensis(LDXGDRALG). Method : Divided SD rats into control, AMK and LDXGD groups (n = 10 per group) at random and administrated orally for 8 weeks with distilled water, AMK (6 g.kg-1), LDXGD乮17.5 g.kg-1, containing AMK 6 g.kg-1乯and LDXGDRALG乮14.5 g.kg-1, containing AMK 6 g.kg-1乯, respectively. Measured renal functional parameters in serum, urine and observe renal histologic lesions at the end of 8 weeks. Result : Three kinds of water abstract induced significantly renal injury in rats, AMK caused the most grievous damage ;LDXGD caused lightest damage and LDXGDRALG reduced more serious damage than LDXGD ,even some parameters of its group were higher than AMK group .Conclusion : AMK and two prescriptions containing AMK in experimental dosage can induce renal injury, and LDXGDRALG reduce more serious damage than LDXGD. It presumpts that the nephrotoxicity of prescriptions containing AMK isn乫t equal to that of AMK , Angelica sinensis,Rehmannia glutinosa Libosch and Glycyrrhizae uralensis in LDXGD may restrict the nephrotoxicity of AMK to a certain degree.

Keywords： Aristolochia manshriensis Kom Long dan xie gan decoction Compatibility Nephrotoxicity