苯并咪唑氨基甲酸酯类药物抗猪囊尾蚴的作用靶点及其效应机理
首发时间:2006-04-07
摘要:应用酶活性和代谢物含量测定技术,对用药后猪带绦虫囊尾蚴能量代谢途径及其关键酶活性进行研究,确定苯并咪唑氨基甲酸酯类抗囊药物对猪带绦虫囊尾蚴的作用靶点为延胡索酸还原酶(FR)复合体,效应机理为抑制葡萄糖的摄取,非竞争性抑制延胡索酸还原酶(FR)复合体活性,导致虫体能量代谢紊乱、能量耗竭,以至死亡。
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Target Position and Effective Mechanism of benzimidazole carbamate against Cysticerci cellulosae
Abstract:Using the technique to detect enzyme activity and metabolite content, the activity of key enzyme in pathway of energy metabolism was studied after drugs were applied. The target position of drug benzimidazole carbamate against Cysticerci cellulosae is fumaric reductase(FR)complex. The effective mechanism is the inhibition of uptaking glucose, noncompetitive inhibition of activity of fumaric reductase(FR)complex, at last disorder of energy metabolism, burnout of energy, and lead to death of Cysticerci cellulosae.
Keywords: Cysticerci cellulosae;target position;effective mechanism;energy metabolism
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No.6133583371144382****
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