DNA甲基化研究方法的回顾与评价
首发时间:2006-04-27
摘要: DNA甲基化是表观遗传学(Epigenetics)的重要组成部分,在维持正常细胞功能、遗传印记、胚胎发育以及人类肿瘤发生中起着重要作用,是目前新的研究热点之一。随着对甲基化研究的不断深入,各种各样甲基化检测方法被开发出来以满足不同类型研究的要求。这些方法概括起来可分为三类:基因组整体水平的甲基化检测、基因特异位点甲基化的检测和新甲基化位点的寻找。本篇将主要介绍目前存在的大部分DNA甲基化研究方法,并对其相关特性进行了简要分析与总结。
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Review and estimation of methylation technology
Abstract:DNA methylation, a very important part in epigenetics, has been playing a pivotal role in retaining normal cell functions, gene imprinting, embryo development, and human tumorigenesis, and now is one of hot area in medical researches. With increasing progresses in the methylation studies, a series of detecting techniques has been developed to match various requirements of methylation studies. All of these study methods can be divided into three groups: genome-wide methylation extent analysis, gene-specific methylation analysis and new methylated sites screening. In this article, we introduced most existing DNA methlylation detecting techniques and summarized their characteristics at the same time.
Keywords: Epigenetics, DNA methylation, methylation detecting technique
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No.6431585861146106****
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