有机磷农药中毒所致神经毒性症状的研究进展
首发时间:2006-09-19
摘要:有机磷杀虫剂(organophosphorus pesticides,OP)是我国目前引起急慢性中毒和致死的主要杀虫剂之一,其产生的神经系统损伤是中毒患者致残和致死的主要原因。除了人们熟知的胆碱能神经兴奋症状、中间综合症(intermediate syndrome,IMS)和有机磷迟发性神经病(organophosphate induced delayed polyneuropathy , OPIDP)等有机磷杀虫剂神经毒性常见症状外,有机磷杀虫剂中毒还可以产生锥体外系症状、脱髓鞘病变和神经肌肉乏力;可以导致神经心理行为缺陷和精神紊乱,特别是有机磷杀虫剂对儿童潜在的神经系统损害没有被人们所认识。因此,正确认识、及时发现有机磷杀虫剂神经毒性影响,对提高治疗疗效、判断患者预后、指导人们生产生活和提高人们生活质量等有重要意义。
关键词: 有机磷杀虫剂,中毒,神经毒性,症状,儿童
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Organophosphorus pesticides, intoxication,neurotoxicity,symptom,child
Abstract:Organophosphorus pesticides (OP), is one of major pesticides used in the farm of acute and chronic intoxication and mortality in China. The central nerve system injury is the major cause of disable and mortality of the patients who intoxicated OP. In addition to the syndromes by cholinergic excitation, intermediate syndrome, and organophosphate induced delayed polyneuropathy, OP intoxication can also induce parapyramidal syndromes, demyelination, and neuromuscular dystrophy, which can cause neruopsychological behavioral disorders. Most importantly, and the effects of OP on children’s nervous system has not been recognized, therefore, it is very important to timely identify the neurotoxicity of OP and its effects to enhance the efficacy of the treatment, assessment of the prognosis, guidance the active work procedure and improve quality of life. The progressive of neurotoxicity in organophosphorus pesticides intoxication research.
Keywords: Organophosphorus pesticides, intoxication,neurotoxicity,symptom,child
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No.8398795691158639****
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