Conductance behavior inside single conical nanopore
首发时间:2006-11-13
Abstract:We investigated the asymmetrical conductance behavior of a polymer based conical nanopore. The current rectification effect happened inside this negatively charged conical nanopore is influenced by the concentration and pH value of the electrolyte. Theoretical analysis and calculation based on Poisson-Nernst-Planck (PNP) equations were conducted to understand the mechanism of the asymmetrical conductance behavior. The difference in transmembrane current at opposite voltage bias is induced by the difference in ionic strength in external field. For pores with extremely tiny tip down to 2 nanometers, its rectification coefficients are particularly high. We attribute this effect to the overlap of the electrical double layer. In addition, we have also demonstrated the model calcium ions detector based on our conical nanopore system. It is sensitive to both pH values of the environmental solution and the concentration of the calcium ions presence, and, its resolution power is high.
keywords: conical nanopore, ion transport, ionic conductance, calcium ion detector
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锥形纳米单孔的导电行为研究
摘要:本文研究了基于高分子聚合物材料的纳米单孔中非对称的导电行为。其中发生的电流校正效应受电解质浓度和pH值的影响。我们对产生这种非对称导电现象的机制作了相关理论探索,给出了基于Poisson-Nernst-Planck (PNP)方程解析计算的结果。发现电流的差异是由于在不同外场作用下,纳米单孔内电解质浓度存在很大差异造成的。实验中还发现,对于只有2纳米尖端的孔,其呈现更大的电流选择效应。我们把这一现象归因为表面双电层的重叠。另外,我们提出了一种基于纳米孔的高分辨率钙离子探测器模型,它可以灵敏分辨钙离子浓度和环境pH值。
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No.9501848081163414****
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