摘除颈上神经节对成年大鼠学习记忆及海马齿状回神经再生的影响
首发时间:2006-11-28
摘要: 通过摘除成年大鼠颈上神经节手术,运用Morris水迷宫测定手术后学习记忆能力的改变,运用DCX标记的免疫组织化学染色方法统计海马齿状回新生神经元的数量,探讨去颈上神经节对成年大鼠海马齿状回神经再生的影响,进而探索交感神经节对哺乳动物学习记忆的调节机制。结果显示,手术组的记忆能力和空间定位能力要显著低于对照组(0.01
关键词: 海马 齿状回 颈上神经节 神经再生
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Influence of superior cervical ganglionectomy to learning,memory and neurogenesis in the dentate gyrus of the adult rat
Abstract:To explore influencing mechanism to mammalian neurogenesis when sympathetic nerve system was injured by accident, surgical procedure, or disease, we have investigated the influence of superior cervical ganglionectomy to neurogenesis in the adult dentate gyrus (DG) of the rat by the methods of immunohistochemistry of DCX marking the new born neurons. Rat underwent superior cervical ganglionectomy or sham procedure. Result showed that in the DCX immunohistochemistry, the number and density of new born neurons (DCX-positive cells) of the operation (the superior cervical ganglia removed rat) were less than the controls’ (sham-removed rat) apparently, statistical analysis compared the average density and number of new born neurons of the operation with the control’s were significant difference (P<0.01). The dendrites of new grown neurons were less and shorter than the controls’. However, the distribution and location of DCX-positive neurons are similar to the controls’. We have concluded that superior cervical ganglionectomy influence neurogenesis in the dentate gyrus of the adult rat.
Keywords: the superior cervical ganglion dentate gyrus neurogenesis doublecortin (DCX)
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No.9958874181164686****
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