川木香对实验性胃溃疡形成的抑制作用研究
首发时间:2007-07-09
摘要:目的:研究川木香对实验性胃溃疡形成的抑制作用。方法:采用利血平型小鼠胃溃疡模型、醋酸型大鼠胃溃疡模型,以雷尼替丁为对照药物,观察动物溃疡指数和溃疡抑制率。结果:川木香单体提取物(去氢木香内酯)、醋酸乙酯提取物、乙醇提取物,抑制利血平型溃疡具有非常显著性意义(与模型对照组比较,P<0.01);醋酸乙酯提取物,抑制醋酸型溃疡具有显著性意义(与模型对照组比较,P<0.05),其中高剂量组作用具有非常显著性意义(与模型对照组比较,P<0.01)。结论:川木香具有抑制实验性胃溃疡的形成作用,醋酸乙酯提取物可以作为川木香抑制胃溃疡形成的有效部位,其作用机理可能与中医传统理论认为川木香具有行气止痛作用有关。
关键词: 川木香 有效提取物 去氢木香内酯 抗溃疡作用 行气止痛作用
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Effects of Radix Vladimiriae on gastric ulcer in rats
Abstract:Objective:To study the effects of Radix Vladimiriae on gastric ulcer in rats. Method:Use the pharmacological model on gastric ulcer induced by reserpine and acetic acid in rats,with Ranitidine as the positive drug,investigate the effects of ulcer index and ulcer inhibition ratio.Result:The extract of Radix Vladimiriae,include Dehydrocostus lactone、acetic ether extract、ethanol extract,can control the gastric ulcer induced by reserpine with greatly statistically significant(P<0.01);acetic ether extract can control the gastric ulcer induced by acetic acid with statistically significant(P<0.05),the higher dosage group set can control the gastric ulcer induced by acetic acid with greatly statistically significant(P<0.01).Conclusion: Radix Vladimiriae extract can control the gastric ulcer,acetic ether extract is the active extract on gastric ulcer in rats,which the mechanism was possibly related to the effects of “Xing Qi Zhi Tong” based on the theory of TCM.
Keywords: Radix Vladimiriae Active extract Dehydrocostus lactone Anti gastric ulcer “Xing Qi Zhi Tong”
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No.1395576266118397****
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