运用染色质免疫沉淀技术筛选AP-2α的靶基因
首发时间:2007-12-26
摘要:在后基因组时代,DNA-蛋白质的相互作用是研究基因表达调控的一个重要领域。染色质免疫沉淀技术(chromatin immunoprecipitation assay, 简称ChIP)是目前唯一研究体内DNA与蛋白质相互作用的方法。本实验运用ChIP实验来筛选转录因子activator protein-2alpha( AP-2α)的未知靶基因。
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Screening target genes of transcription factor AP-2alpha by chromatin immunoprecipitation assay
Abstract:In the post-genomic era, identifying and characterzing various DNA-protein interactions are a major challenge in the research of gene transcriptional regulation. Now, chromatin immunoprecipitation assay (ChIP) is ideally suited for studying DNA-protein interactions in vivo. In this study, we utilized chromatin immunoprecipitation assay to screen unknown target genes of transcription factor AP-2alpha.
Keywords: chromatin immunoprecipitation assay, target gene, activator protein-2alpha
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No.1741492814119864****
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