阿霉素海藻酸钠微球药代动力学的动物实验研究
首发时间:2007-12-31
摘要:目的 研究阿霉素海藻酸钠微球在实验动物体内的药代动力学。材料与方法 中华小型猪10头,随机分为3组,动脉造影后超选择至肝动脉分支,实验组行阿霉素海藻酸钠微球肝动脉化疗栓塞,两个对照组分别行碘油阿霉素肝动脉化疗栓塞和单纯阿霉素肝动脉灌注;药物注射结束后定时(15分钟、30分钟、1小时、2小时、4小时、1天、2天、3天、1周、2周、4周、8周)取实验动物的外周静脉血,采用高效液相色谱法(HLPC)测定其血药浓度并进行药代动力学方面的相关统计处理。结果 阿霉素海藻酸钠微球与单纯多柔比星溶液灌注、碘油多柔比星栓塞相比,在血浆半衰期﹑药时曲线下面积(AUC)和平均滞留时间(MRT)等方面均显著延长(P<0.01或P<0.05)。结论 阿霉素海藻酸钠微球在肝脏内具有明显缓释性,可以显著延长药物在体内的停留时间。
关键词: 阿霉素;海藻酸钠 微球;药代动力学;动物 实验
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Study of pharmacokinetics about adriamycin alginate microspheres
Abstract:Objective To investigate the pharmacokinetics of adriamycin alginate microspheres in vivo. Materials and methods Ten miniature pigs were randomly divided into three groups. Transcatheter hepatic arterial chemoembolization with adriamycin alginate microspheres (group1, n=4), lipiodol and adriamycin (group2, n=3), infusion of adriamycin alone (group3, n=3) were performed after angiography and superselection of an intrahepatic branch of hepatic artery. After chemoembolization or infusion, the animals were phlebotomized at different intervals. Drug concentration of peripheral vein was measured by HLPC and parameters of pharmacokinetics were calculated afterwards. Results AUC and MRT of the experimental group were significantly higher than that of groups 2 and 3 (p<0.05). Infarct areas in the livers of the experimental group were found at follow-up CT. Conclusion Adriamycin alginate microspheres show definite properties in both delayed release of drug and efficiency of embolization.
Keywords: Adriamycin Sodium alginate, microsphere Pharmacokinetics Animal, experiment
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No.1762717920211990****
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