P(VP-b-DLLA)嵌段共聚物的合成与自组装
首发时间:2008-03-17
摘要:以萘钠为引发剂,以聚乳酸(PDLLA)为疏水链段,聚乙烯基吡咯烷酮(PVP)为亲水链段,采用阴离子聚合方法合成了新型P(VP-b-DLLA)两亲性生物可降解嵌段共聚物医用高分子材料。通过傅立叶红外光谱(FT-IR)、核磁共振谱(1H-NMR)、热重和元素分析等手段对合成的两亲性嵌段共聚物进行了表征。采用透射电镜(TEM)、动态激光光散射(DLS)和荧光分光光度计等技术研究了嵌段共聚物在选择性溶剂中的自组装行为。
关键词: 可生物降解材料 阴离子聚合 自组装 P(VP-b-DLLA) 嵌段高分子
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Synthesis and Self-assembling of P(VP-b-DLLA) Diblock Copolymer
Abstract:Combined 2-mercaptoethanol with isopropyl alcohol as chain transfer agents, poly(N-vinyl-2-pyrrolidinone)-block-poly(D,L-lactide) P(VP-b-DLLA) having hydroxyl-end groups was synthesized by anionic polymerization. The well-defined diblock copolymer can be self-assembled into micelles in a selective solvent. Micellization behavior of P(VP-b-DLLA) in a selective solvent was characterized by dynamic light scattering, turbidity measurements, fluorescence probe technique, and transmission electron microscopy. These results suggested that the P(VP-b-DLLA) was a potential drug carrier in functionalized biodegradable and biocompatible drug delivery system.
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No.1936410252612057****
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