富勒烯缬氨酸衍生物的合成
首发时间:2008-04-30
摘要:富勒烯的特殊笼形结构使其在化学、物理、生物学等科领域都具有很好的研究价值,由于富勒烯本身不溶于水,所以研究富勒烯的生物学效应的前提是将富勒烯球进行化学修饰,得到的产物具有良好的溶解性。因此本文将α-氨基被保护的缬氨酸在HOBt、缩合剂DIC的作用下进行羧基活化,然后与中间体N-取代的 3,4-富勒烯吡咯烷衍生物的羟基进行缩合反应,得到产物富勒烯缬氨酸。采用MALDI-TOF质谱、紫外可见光谱、红外光谱、核磁共振1HNMR 等分析方法对其进行了结构表征。
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Synthesis of [60]fullerene α-aminoisovaleric acid derivatives
Abstract:Fullerene which possess unique spheroidal shapes display a wide range of interesting chemical, physical and biological properties. Because of the limited solubility of fullerene in aqueous solution, the biological effect of fullerenes can be achieved by covalent attachment of appendages on their globular framework. So the production can solve in organic solvents. Amino-isovaleric acid with protected α-amino group was activated on the effect of HOBt and condensing agent DIC, then it had been used to react with N-substituted 3,4-fullero pyrrolidine, so [60]fullerene α-aminoisovaleric acid derivatives was obtained. The chemical structures was characterized by MALDI-TOF-MS, UV-VIS, FTIR and 1HNMR.
Keywords: Fullerene [60]fullerene α-aminoisovaleric acid derivatives Synthesis
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No.2102221691412095****
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