Anticoagulant and Antiproliferative activity of heparin from
首发时间:2008-04-08
Abstract:Heparin was isolated from two bivalve mollusks such as Tridacna maxima and Perna viridis. The isolated heparin was quantified in crude as well as purified samples and they were estimated as 2.72 & 2.2 gm / kg (crude) and 260 & 248 mg/gm (purified) in T. maxima and P. viridis respectively. Both the bivalves shown the anticoagulant activity of the crude and purified sample 20,128 USP units per kg and 7.4 USP units per mg and 39,000 USP units per kg and 75 USP units per mg and 9,460 USP units per kg and 4.3 USP units per mg and 13,392 USP units per kg and 54 USP units per mg correspondingly in T. maxima and P. viridis. The antiproliferative activity was studied with pulmonary artery smooth muscle cells (PASMC) using RPMI media reported that the result in a dose dependent manner. Among the two clams, P. viridis showed more antiproliferative activity than that of T. maxima.
keywords: antiproliferation glycosaminoglycans giant clam green mussel heparin.
点击查看论文中文信息
Anticoagulant and Antiproliferative activity of heparin from
摘要:Heparin was isolated from two bivalve mollusks such as Tridacna maxima and Perna viridis. The isolated heparin was quantified in crude as well as purified samples and they were estimated as 2.72 & 2.2 gm / kg (crude) and 260 & 248 mg/gm (purified) in T. maxima and P. viridis respectively. Both the bivalves shown the anticoagulant activity of the crude and purified sample 20,128 USP units per kg and 7.4 USP units per mg and 39,000 USP units per kg and 75 USP units per mg and 9,460 USP units per kg and 4.3 USP units per mg and 13,392 USP units per kg and 54 USP units per mg correspondingly in T. maxima and P. viridis. The antiproliferative activity was studied with pulmonary artery smooth muscle cells (PASMC) using RPMI media reported that the result in a dose dependent manner. Among the two clams, P. viridis showed more antiproliferative activity than that of T. maxima.
关键词: antiproliferation; glycosaminoglycans; giant clam; green mussel; heparin.
基金:
论文图表:
引用
No.2017720595212076****
同行评议
共计0人参与
勘误表
Anticoagulant and Antiproliferative activity of heparin from
评论
全部评论0/1000