不同应激因子诱导小白鼠肝脏金属硫蛋白合成的影响
首发时间:2008-07-31
摘要:本研究从时间—效应和剂量—效应两方面研究了重金属元素(Cd)、微量元素(Zn)、重金属与微量元素的组合(Cd+Zn)、生理因子(饥饿)及创伤因子(割背部肌肉见骨)等5大类组合应激因子、19种诱导方式对小白鼠肝脏中金属硫蛋白(MT)诱导合成的影响及效果,以筛选出MT合成量最大的诱导因子。实验结果表明:生理因子诱导MT量最小,饥饿诱导小白鼠肝脏MT的量随饥饿程度的加重而增加,但各组间差异不显著(P﹥0.05);创伤因子诱导产生MT的量最高,其诱导量随创伤恢复时间的增加而降低,各组之间差异显著(P﹤0.01),本实验诱导峰值(9.0241±0.6441µmol/g)出现在创伤后6h;重金属元素和微量元素诱导量居中,且两者混合诱导量比单独诱导量之和要大。
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Effects of Different Stress Factors on Metallothionein Synthesis in Mouse Liver
Abstract:Trauma, starvation, zinc (Zn), cadmium(Cd), Zn–Cd mixture, all together five kinds of stress factors and 19 treating ways, were used as inducers to induce the production of metallothionein in Kunming mouse liver designed according to time-effect and dose-effect relationship, in order to find the best treating way that could induce the most production of metallothionein. Results shew that: a)The production of metallothionein induced by starvation was the least among all inducers , the longer mice-hungry time and the higher production of metallothionein was induced, but there were no significant (P>0.05) differences between every two groups. b) Among all stress factors, the production of metallothionein induced by trauma was the highest, the longer trauma-recovery time and the lower production of metallothionein was induced. The production climax(9.0241±0.6440µmol/g) of metallothionein induced came out among 1~12h after trauma, and there were significant (P<0.01) differences between every two groups. C) The production of metallothionein induced by Zn and Cd was less than that of Zn-Cd mixture, but all of them lied between that of trauma and starvation groups.
Keywords: Metallothionein Stress factor Induce Synthesis Kunming mouse
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No.2317629306612174****
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