Gender- and Age-Related Differences in the Morphology of Corpus Callosum: by MR imaging

• 1、Medical College of Lan Zhou University
• 2、Radiology department of lanzhou university second hospital

Abstract：Purpose: To investigate the morphological characteristic of Corpus callosum(CC) with gender and age. Materials and methods: 240 healthy objects with MR examination were grouped by gender and age, the length of CC (LC), width of genu (WG), width of trunk (WT), width of splenium (WS), splenium areas(Sa), CC areas (CCa), cerebrum areas, additionally Sa-CCa ratio (SCR) and CCa-CBa ratio (CBR) were measured on mid-sagittal section with SE-T1WI. Statistical analysis, scatter plot and curve fitting between these index and age were completed by SPSS software. Results: ① Mean LC, WG, Sa, CCa and CBR of normal males were larger and SCR was smaller than that of females (p<0.05), there were no difference of WT and WS for gender (P>0.05). ② Significant difference of these index across different age groups were testified by LSD-test (P<0.05), it implied that growth curves of LC, WS and Sa followed logarithmic curves across the human lifespan, and that of WT, WG, CCa and CBa followed inverted quadratic term -curves across the human lifespan, the optimal equation for CCa(Y)-ages(X) was [Y=460.663+10.538×(age)–0.124×(age)2 ]. Conclusion Significant difference of CC size with gender and age was clearly demonstrated in this study. The length of CC increases as age, The total area of CC, width of genu and width of trunk increase as age before (30-40) years old, and decrease as age after this years old, it predicts that the changes of these index follows an inverted quadratic term -curve across the human lifespan.

Keywords： corpus callosum magnetic resonance imaging Morphology gender age