海洋多环胍类生物碱的研究进展
首发时间:2008-10-29
摘要:海洋生物是获取结构新颖的、具有多种生物活性的次级代谢产物的重要来源。以ptilomycalin A为代表的海洋多环胍类生物碱具有独特的结构和多样的生物活性。本文对来源于海洋生物(如海绵、海星)的、与ptilomycalin A具有相似生合成途径的ptilocaulin(mirabilin)类、crambecin类、batzelladine类和crambescidin类等多环胍类生物碱的结构类型、生物活性以及提取分离方法等进行了归纳总结。海洋多环胍类生物碱结构中通常具有双环胍、三环胍或五环胍结构,并且具有抗病毒、抗HIV、抗菌、抗真菌、抗恶性疟原虫和肿瘤细胞毒等作用,其中五环胍的ptilomycalin A类和三环胍的batzelladine类生物碱正在作为抗HIV、抗肿瘤先导物进行深入的研究。
关键词: 海洋多环胍类生物碱 ptilomycalin A batzelladine 抗病毒 抗肿瘤
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Progress on the Study of Marine Polycyclic Guanidine Alkaloids
Abstract:Marine organisms have become an important source of the novel and biologically active secondary metabolites. Marine polycyclic guanidine alkaloids such as ptilomycalin A, have unique structures and diverse biological activities. In this paper, studies on the structural types, biological activities, and extraction and isolation methods of polycyclic guanidine alkaloids of ptilocaulins (mirabilin), crambecins, batzelladines, and crambescidins which has the similar biosynthesis pathway to ptilomycalin A isolated from sponges and starfishes are reviewed. The marine polycyclic guanidine alkaloids have bicyclic, tricyclic, and pentacyclic structure moiety and have antiviral, anti-HIV, antimicrobial, antifungal, and antimalarial activities and cytotoxicity to tumor cell lines. Among them, pentacyclic ptilomycalins and tricyclic batzelladines are under study as anti-HIV and antitumor lead compounds.
Keywords: marine polycyclic guanidine alkaloid ptilomycalin A batzelladine antivirus antitumor
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No.2524634001612252****
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