度洛西汀中间体(S)-N,N-二甲基-3-羟基-3-(2-噻吩基)-丙胺
首发时间:2008-12-15
摘要:目的:采用酶法合成度洛西汀中间体(S)-N,N-二甲基-3-羟基-3-(2-噻吩基)-丙胺。方法:考察反应温度、pH值、反应时间及酶量对反应结果的影响,得到优化反应条件。结果:通过酶法合成了(S)-N,N-二甲基-3-羟基-3-(2-噻吩基)-丙胺。结论:最佳反应条件为:温度40℃, pH 7.0,反应时间24 h,用酶量60万单位时,产物的得率达76%。 酶法合成提高了S)-N,N-二甲基-3-羟基-3-(2-噻吩基)-丙胺的收率和光学纯度。
关键词: (S)-N,N-二甲基-3-羟基-3-(2-噻吩基)-丙胺 酶法 合成
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Study on the synthetic process of Duluoxetine Intermediat
Abstract:Objective: To synthesize Duluoxetine Intermediat (S)-N,N-dimethyl-3-(2-thienyl)- Propanamine by Enzymatic. Method: inspection system temperature、pH、time and Enzyme measurement affected the outcome of the reaction, has been optimized conditions. Results: the adoption of new methods of synthesis of the target product. Conclusion: The best conditions are as follows: reaction temperature 40℃, pH 7.0, time 24h and Enzyme measurement 0.6 million,the yield is up to 76 percent. To improve the yield and optical purity of (S)-N,N-dimethyl-3-(2-thienyl)-Propanamine by Enzymatic.
Keywords: (S)-N,N-dimethyl-3-(2-thienyl)-Propanamine Enzymatic synthesis
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