盐酸川芎嗪w/o微乳的制备及质量评价
首发时间:2009-01-21
摘要:目的:制备盐酸川芎嗪微乳。方法:采用伪三元相图法结合稳定性考察优选处方。结果:优选盐酸川芎嗪微乳处方为:OP为乳化剂,丙三醇为助乳化剂,油酸乙酯为油相,盐酸川芎嗪水溶液浓度为50mg/mL。四者比例为4:4:2:0.95(25℃)时制剂稳定。平均载药量为8.0417mg/mL。结论:该方法简单,重现性好,制剂稳定。
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Preparation and Quality Evaluation of Ligustrazine Hydrochloride Microemulsion
Abstract:Aim: Preparation of Ligustrazine Hydrochloride microemulsion; Method: Applying pseudo-ternary phase diagrams and stability investigation to optimaize the prescription; Conclusions: The optimal condition of preparation of Ligustrazine Hydrochloride Microemulsion is using OP as emulsifier, glycerol as coemulsifier, ethyl oleate as oil phase and Ligustrazine Hydrochloride solution 50mg/mL, The most stable proportion was 4:4:2:0.95(25℃). The average drug loading was 8.0417mg/mL. Result: Thise method was simple and stable.
Keywords: ligustrazine hydrochloride microemulsion preparation
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