Mechanism for alternating electric fields induced-effects on cytosolic calcium

• 1、College of Physics, Nankai University

Abstract：Interest in hazardous consequences of so-called ‘electromagnetic pollution’ is increasing within the scientific community. In this work, from the point of calcium ions in the cytosol, we extended a Vm-[Ca2+]cyt model to explain the changes of action potential (Vm) of the plasma membrane and the calcium concentration in the cytosol ([Ca2+]cyt) under an alternating electric field in cells. An alternating external electric field may exert an oscillating force () to each of the free electrolytes, existing on both sides of the plasma membrane. The mechanism for the alternating electric field induced-effects on Vm and [Ca2+]cyt was elucidated. The simulated results showed a correlation between the changes of [Ca2+]cyt and the alternating electric field. When the numerical ratio between the intensity E0 (mV/m) and the frequency (Hz) of the field was about 1~2, the [Ca2+]cyt signal was changed dramatically. The bioactive changes of [Ca2+]cyt appeared at low frequency, at the range of 0~100Hz.

Keywords： Alternating electric field, Transmembrane action potential, Calcium concentration, Ion channels