抗污染超滤膜在金芪降糖片原料药精制中的应用
首发时间:2009-03-25
摘要:膜分离技术广泛应用于中药生产。该文将超滤膜用于精制中药金芪降糖片原料药黄连、黄芪和金银花的研究。通过对三种原料药及其混合物超滤性能的考察,确认了PES/Pluronic F127抗污染超滤膜对真实中药体系的适用性。研究表明在精制过程中应用抗污染超滤膜,可对黄连中小檗碱、黄芪中黄芪多糖和金银花中绿原酸进行高效分离提纯,同时对去除固体悬浮物,提高药液澄明度也有显著效果。通过比较不同精制方式,设计了基于超滤的中药生产新工艺,该工艺具有工序少,处理能力大,成本低的特点。
关键词: 膜分离 金芪降糖片 超滤 聚醚砜 Pluronic F127
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Application of antifouling polyethersulfone ultrafiltration membrane in refinement of traditional Chinese medicine Jinqi Jiangtang Pian
Abstract:The membrane separation is extensively applied in the production of traditional Chinese medicine. In this paper, we introduced ultrafiltration to refinement of traditional Chinese medicine Jinqi Jiangtang Pian, including Rhizoma Coptidis, Radix Astragali, and Flos Lonicerae Japonicae. In order to investigate the applicability of PES/Pluronic F127 antifouling membranes in real medicine system, the ultrafiltration performances of three raw materials and their mixtures were all measured, respectively. The results show that the application of antifouling ultrafiltration membranes in refinement could effectively separate and purify Berberine, AstragalosideIV, and Chlorogenic acid from Rhizoma Coptidis, Radix Astragali and Flos Lonicerae Japonicae, respectively. Meanwhile, the clarity of solutions could be improved as well as the suspended solids could be eliminated. Finally, the inherent relationship between medicine solutions and antifouling membranes was studied; and the guidance for rational design of new process based on ultrafiltration was tentatively presented.
Keywords: membrane separation Jinqi Jiangtang Pian ultrafiltration polyethersulfone Pluronic F127
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No.3070622269123794****
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