兔动脉粥样硬化模型的证候归属研究
首发时间:2009-04-09
摘要:目的:建立兔动脉粥样硬化模型,对此模型进行中医证候学归属性研究。方法:24只雄性日本大耳白家兔随机分为空白组(8只)和实验组(16只),空白组给予普通饲料,实验组在高脂饮食的基础上加以免疫损伤和经股动脉球囊损伤术,共饲养10周。用血管形态学观察以及TG、TC、LDL-C评价模型,并定期观察家兔的耳、舌、眼睛以及整体状态等证候学变化。结果:实验组家兔初期为气虚、中期为气虚痰凝、后期为气虚血瘀之证。结论:此方法建立的动脉粥样硬化兔模型证候学是变化的,其规律与临床动脉粥样硬化的发病相似。
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Study of Syndrome attribution in Atherosclerosis model of Rabbit atherosclerosi
Abstract:Objective: To establish a rabbit model of atherosclerosis, this model study of TCM syndrome study attribution. Methods: 24 male Japanese rabbits were randomly divided into blank group (8) and experimental group (16), a blank group were given normal diet, the experimental group at the basis of high-fat diet to be immune injury and the femoral artery balloon-injured patients, keeping a total of 10 weeks.Morphological observation of blood vessels as well as the use of TG, TC, LDL-C evaluation model, and regular observation of rabbit ear, tongue, eyes and overall card status, such as changes in phenology. Results: Experimental group rabbits is Qi-deficiency in early time, Qi-deficiency and Solidification of sputum in medium-term, late on the card for Qi -deficiency and Blood-dtasis. Conclusion: This method of rabbit atherosclerosis syndrome study are changes in its laws and clinical atherosclerosis is similar to the incidence.
Keywords: Atherosclerosis Syndrome Methods Qi-deficiency and Solidification of Sputum Qi Deficiency and Blood Stasis
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