Bionic design and flow of blood in artificial liver fibers

• 1、Department of Mechanical Engineering, Zhengjiang University

Abstract：The adherence, the share rate and the breakage of cells in the blood flow are key problems for the optimal design of artificial liver fibers. In order to estimate the Fahraeus and Fahraeus-Lindqvist effects of blood flow in fibers, numerical models are proposed to calculate rheology parameters versus fiber radius of small artery and small vein under different Hct. The results show that the higher Hct is, the higher the yield stress is at the same shear rate and the blood velocity increases as the Hct decreases. The velocity in small artery is lower than that in small vein, but the flux is the opposite situation. The share strength of blood at central vessel is lower than that at the inner surface. The share strength of small vein is lower and the adhesive time is shorter than those of small artery. The adhesive time declines dramatically as the unit pressure drop increases and vessel radius. If design is impropriate, the red blood cells at inner surface of the vessel will easily be broken as the result of high share stress. The models of Fahraeus and Fahraeus-Lindqvist effects can be used to optimize the design of fiber vessel radius, and calculate blood velocity, adherence and share stress in artificial liver.

Keywords： artificial liver bionics adherence share rate flow