缩泉丸对肾阳虚多尿大鼠肾脏AQP2蛋白表达的影响
首发时间:2009-07-06
摘要:目的:观察缩泉丸对肾阳虚多尿模型大鼠水通道蛋白2(AQP-2)蛋白表达的影响。方法:用腺嘌呤250mg/kg灌服大鼠4周,造成肾阳虚多尿模型,分别给予缩泉丸和去氨加压素治疗4周,用Westerblot法和免疫组化法检测缩泉丸对肾阳虚多尿模型大鼠肾脏AQP-2蛋白表达的影响。结果:肾阳虚多尿模型组大鼠肾脏AQP-2蛋白表达比正常对照组明显降低, dDAVP组和缩泉丸低、中、高剂量组AQP-2表达比模型组明显升高。结论:缩泉丸够提高肾阳虚多尿大鼠肾脏AQP-2的蛋白表达。
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Impacts of the formula of Suoquanwan(SQW) on expression of AQP-2 in the Kidney of rat polyuria model of Yang-deficiency
Abstract:Objective:To observe the impacts of the formula of Suoquanwan(SQW) on expression of AQP-2 in the Kidney of rat polyuria model of Yang-deficiency Method: The model rats were induced by adenine(250mg/kg) for 4 weeks, then treated respectively with SQWand dDAVP. Expression of AQP-2 in kidney of Yang-deficiency model by Western Blot and immunohistochemistry method was investigated.. Results:In model rats, expression of AQP-2 in the Kidney were decreased,dDAVP and SQW can increased the expression of AQP-2 in the Kidney. Conclusion:SQW can increase expression of AQP in the Kidney of the rat polyuria model of Yang-deficiency .
Keywords: Suoquanwan polyuria model of Yang-deficiency AQP-2
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