益肾胶囊对慢性肾小球肾炎患者免疫功能的影响
首发时间:2009-07-06
摘要:目的:观察益肾胶囊对慢性肾小球肾炎(慢性肾炎,chronic glomerulonephritis,CGN)患者免疫功能的影响。方法:分别采用酶联免疫双抗体夹心法、流式细胞仪及免疫比浊法检测了40例健康查体者和78例患者治疗前后血浆sEPCR、CD62P及血清免疫球蛋白(Ig)、补体3水平的改变。结果:治疗前慢性肾炎患者血浆sEPCR、CD62P及血清IgA水平均明显升高(P<0.01),血清IgG、IgM及补体C3水平明显降低(P<0.01),经过3个月的治疗,治疗组患者血浆sEPCR、CD62P及血清IgA水平明显下降(P<0.05或P<0.01),IgG、IgM及补体C3明显升高(P<0.05或P<0.01)。结论:益肾胶囊调整CGN患者机体免疫功能的作用可能与降低血浆sEPCR、CD62P水平及调节血清IgA、IgG、IgM和补体C3水平有关
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he effects of YiShen Capsule on the immunological function in patients with Chronic Glomerulonephritis
Abstract:Objective: To investigate the effects of YiShen Capsule on the immunological function in patients with chronic glomerulonephritis (CGN). Methods: The level changes of sEPCR 、CD62P in plasma and immune globulin 、complement 3 (C3) in serum were assessed in 40 normal subjects and 78 patients before and after treatment by double- antibody enzyme- linked immunosorbent assay、flow cytometry and immunoturbidimetry individed .Results: Compared with normal group before treatment,the levels of sEPCR 、CD62P in plasma and IgA in serum were increased obviously (P<0.01), and the levels of IgG、IgM、C3 in serum decreased significantly(P<0.01). After three months treatment with YiShen Capsule,the levels of sEPCR 、CD62P in plasma and IgA in serum were decreased significantly than before treatment (P<0.05 or P<0.01), and the levels of IgG、IgM、C3 in serum increased obviously. Conclusion: The effects of YiShen Capsule adjusted the immunological function in patients with CGN maybe correlate with decrease the levels of sEPCR 、CD62P in plasma and regulate the levels of immune globulin and C3.
Keywords: YiShen Capsule chronic Glomerulonephritis Immunological Function
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