非综合征性唇腭裂环境危险因素的病例对照研究
首发时间:2009-07-30
摘要:目的 分析非综合征性唇腭裂(nsCL/P)与孕早期环境暴露因素之间的关系。方法 采用自行设计的调查表,通过面对面询问研究对象的父母亲获取问卷资料。运用单因素及多因素非条件Logistic回归模型分析环境危险因素与nsCL/P的关联性。结果 与对照组相比,病例组父母的文化程度较低(P=0.000),病例组中农民所占比例较高(P=0.000)。在调整了父母的文化程度和职业分布的影响后,多因素分析结果显示母亲孕早期被动吸烟(OR=1.643)、母亲孕早期感染史(OR=2.741)、父亲知晓怀孕前饮酒(OR=1.793)与nsCL/P的发病风险有关,是nsCL/P发生的危险因素。结论 怀孕夫妇在孕早期应避免烟酒等不良嗜好并注意防止感染的发生,以减少后代患唇腭裂的风险。
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A case-control study of Environmental Risk Factors in the Development of Nonsyndromic Cleft Lip with or without Cleft Palate
Abstract:Objective To analyze the effects of environmental factors in the first trimester of pregnancy on nsCL/P. Methods A face to face questionnaire interview to parents of subjects was conducted to collect data. The environmental risk factors were analyzed by unconditional univariate and multivariate logistic regression models. Results Educational level was lower for the cases’ mothers or fathers compared with the controls’ (P=0.000). In occupational distribution of subjects’ parents, the ratio of peasants in the case group is higher than that in the control group (P=0.000). The results of multivariate analysis after adjusting educational levels and occupations of father and mother showed that maternal passive smoking (OR=1.643), infection (OR=2.741) in the first trimester of pregnancy, paternal high-risk drinking (OR=1.793) before realizing pregnancy were significant risk factors of nsCL/P. Conclusion It is an important measure to prevent nsCL/P to avoid smoking, drinking and infecting for gestation couples.
Keywords: Nonsyndromic cleft lip with or without cleft palate The first trimester of pregnancy Environmental factors
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No.3418037217912489****
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