脂肪因子Apelin的研究进展
首发时间:2009-08-19
摘要:Apelin是一种新的脂肪细胞因子,是孤儿G蛋白偶联受体—血管紧张素受体样蛋白J受体(APJr)的内源性配体,在组织中广泛分布。它与肥胖、胰岛素抵抗、心血管系统等关系密切,同时,最新研究表明,Apelin对肺动脉高压、进食活动、神经内分泌、免疫调节等方面都发挥了重要作用,本文就apelin /APJr系统的生理病理作用进行综述。
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The Role Played in Human physiopathology and Potential Therapeutic Applications for apelin
Abstract:Apelin is a peptide recently isolated from bovine stomach extracts which appears to act as an endogenous ligand for the previously orphaned G-protein-coupled APJ receptor, it has been described as an adipocyte-secreted factor (adipokine) in 2005. Apelin and its receptor APJ are expressed in both the central nervous system and peripheral tissues. Consistent with this pattern of distribution, Apelin /APJr have been shown multiple biological effects such as regulation of cardiovascular functions, fluid homeostasis, vessel formation, cell proliferation, type 2 diabetes and metabolism or eating behavior. This review will consider the main roles of apelin in physiopathology.
Keywords: Apelin APJr adipokine New Research Progress
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No.3455825092212506****
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