阻塞性睡眠呼吸暂停低通气综合征与动脉粥样硬化的研究
首发时间:2010-01-06
摘要:目的:阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome, OSAHS)是一种较常见的疾病。其基本的病理生理的改变为睡眠时的反复间断低氧(Intermittent Hypoxia, IH)这种情况会导致OSAHS患者并发许多心血管疾病,包括高血压,心肌梗死和中风。未经治疗的严重的OSAHS患者5年的病死率高达11%-13%,其死亡的主要原因为该病导致的心脑血管并发症。夜间反复的间断低氧在心血管疾病的发生和进展中的作用还不是很明确,但是IH引起的血管内皮损伤及IH引起的系统性炎症及代谢紊乱并由此导致的动脉粥样硬化形成在心血管疾病的发生、发展的作用越来越引起人们的重视。有效的治疗OSAHS是否可以有效的降低其心脑血管疾病的发生有待于进一步研究。
关键词: 阻塞性睡眠呼吸暂停低通气综合征 动脉粥样硬化 间断低氧
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Obstructive sleep apnea-hypopnea syndrome And the Atherosclerosis
Abstract:Objective Obstructive sleep apnea-hypopnea syndrome is a common disease. The basic changes in the pathophysiology was repeated intermittent hypoxia during sleep, and this will lead to OSAHS patients complicated with many cardiovascular diseases, including hypertension, myocardial infarction and stroke. Untreated severe OSAHS patients with 5-year case fatality rate as high as 11% -13%, the leading cause of death as a result of cardiovascular disease complications. Night repeated intermittent hypoxia on cardiovascular disease incidence and progression is unknow ,but IH and IH vascular endothelial injury caused by systemic inflammation and metabolic disorders, and the resulting formation of atherosclerotic cardiovascular diseases, role in development has drawn increasing attention. Effective treatment for OSAHS whether it can effectively reduce the incidence of cardio-cerebral vascular diseases remains to be studied further.
Keywords: obstructive sleep apnea-hypopnea syndrome Atherosclerosis intermittent hypoxia
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阻塞性睡眠呼吸暂停低通气综合征与动脉粥样硬化的研究
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