穿心莲内酯衍生物的合成及α-葡萄糖苷酶抑制活性
首发时间:2010-01-20
摘要:利用插烯缩合反应,合成了系列的穿心莲内酯衍生物,并评价了其α-葡萄糖苷酶抑制活性。结果表明新合成的化合物表现出了良好的α-葡萄糖苷酶抑制活性,其中化合物9a,9b,9c,9g的IC50值分别达到了15.7,8.3,14.1和24.6µМ。
关键词: 穿心莲内酯 α-葡萄糖苷酶抑制活性 合成
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Synthesis andα-Glucosidase Inhibitory activity of Andrographolide Derivatives
Abstract:A series of andrographolide derivatives were synthesized by way of vinylogous aldol reaction. Their α-Glucosidase Inhibitory activity was also investigated. The results showed that most of them have good α-Glucosidase Inhibitory activity. Among them compounds 9a, 9b, 9c and 9g were the best inhibitors with the IC50 of 15.7, 8.3, 14.1 µM respectively.
Keywords: andrographolide α-Glucosidase Inhibitory activity synthesis
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No.3926951116212639****
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